Houseguests. Lois shares her apartment with a fugitive convicted murderer she believes is innocent and Clark has a new roommate:Jonathan who fears Martha is having an affair with a younger man.
Lois follows a trial about a possible killer, Eugene Laderman , who she believes is innocent despite he is convicted of killing Henry Harrison, the husband of Eugene's lover, Lena. Eugene escapes and hides at Lois' apartment while Lois tries to prove his innocence.
Lois and Clark's investigation leads them to discover that Lean is acting strange for someone who grieves her husband and lover's conviction while at the same time, a virus called "The Ides of Metropolis" that Henry was working on, takes over all the computers of the country.
Eugene is the only one who can find the antidote to it and with the help of Superman, they manage to stop the virus before it is too late. While Superman and Eugene work for the antidote, Lois and Detective Reed find out that Henry is not dead and along with Lena are behind the virus. When everything is done, Reed arrests Henry and Lena.
Meanwhile, Jonathan arrives at Clark's house after fighting with Martha because he believes that she is having an affair, but when Martha comes to see him, things get straightened out.